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Borna disease, a possible hazard for man?

R Rott1, S Herzog, K Bechter

  • 1Institute für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.

Archives of Virology
|January 1, 1991
PubMed
Summary

Borna disease virus (BDV) may infect humans, potentially causing mental disorders. Researchers found BDV-specific antibodies in psychiatric patients, suggesting a link between this animal virus and human neurological conditions.

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Area of Science:

  • Neurovirology
  • Psychiatry
  • Immunology

Background:

  • Borna disease virus (BDV) is a known encephalitogenic agent in animals.
  • Previous research has primarily focused on BDV's impact on veterinary medicine.

Purpose of the Study:

  • To investigate the potential role of Borna disease virus (BDV) or related agents in human mental disorders.
  • To determine the prevalence of BDV-specific antibodies in psychiatric and neurological patient populations.

Main Methods:

  • Serological screening of over 5000 patients from Germany, USA, and Japan for BDV-specific antibodies.
  • Immunological assays using BDV-specific proteins derived from cloned viral RNA.
  • Inoculation of cerebrospinal fluid from seropositive patients into rabbits and rabbit brain cell cultures.

Main Results:

  • BDV-specific antibodies were detected in 4-7% of sera from psychiatric/neurological patients.
  • Antibodies from seropositive patients recognized a BDV-specific viral protein.
  • Cerebrospinal fluid from seropositive patients showed evidence of BDV or a related agent upon inoculation.

Conclusions:

  • The findings suggest that Borna disease virus (BDV) or a related agent may infect humans.
  • A potential association between BDV infection and the induction of mental disorders in humans is indicated.
  • Further research is warranted to confirm the etiological role of BDV in human psychiatric conditions.

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