Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
Atomic Fluorescence Spectroscopy01:29

Atomic Fluorescence Spectroscopy

Atomic fluorescence spectroscopy (AFS) is an analytical technique that involves the electronic transitions of atoms in a flame, furnace, or plasma being excited by electromagnetic (EM) radiation. When these atoms absorb energy, they become excited and subsequently release energy as they return to their original state. This emitted light, or "fluorescence," is observed at a right angle to the incident beam. Both absorption and emission processes transpire at distinct wavelengths, which are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Factors Associated with the Health-Related Quality of Life in Pregnant Women in the second and Third Trimesters: Evidence from Jiangsu Province, Eastern China.

International journal of women's health·2026
Same author

The role of m6A modification in spermatogenic dysfunction.

Molecular biology reports·2026
Same author

Risk Factors for Severe Postpartum Hemorrhage in Vaginal Delivery: A Retrospective Cohort Study.

Maternal-fetal medicine (Wolters Kluwer Health, Inc.)·2026
Same author

Decarboxylative alkylation of alkenes.

Nature·2026
Same author

Synthesis of 1,3-Dienes from Alkenes via Alkenyl Thianthrenium Salts.

Journal of the American Chemical Society·2026
Same author

Thianthrenium Salts in Photochemistry.

Accounts of chemical research·2026

Related Experiment Video

Updated: Jun 10, 2026

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
10:10

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

Published on: July 28, 2018

Silver-catalyzed late-stage fluorination.

Pingping Tang1, Takeru Furuya, Tobias Ritter

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|August 11, 2010
PubMed
Summary

This study introduces silver catalysis for creating carbon-fluorine bonds, a significant advancement in synthesizing aryl fluorides. This novel method offers broad functional group tolerance and substrate scope, surpassing existing palladium-based approaches.

More Related Videos

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
08:33

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

Published on: June 28, 2011

Related Experiment Videos

Last Updated: Jun 10, 2026

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
10:10

Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes

Published on: July 28, 2018

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
08:33

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

Published on: June 28, 2011

Area of Science:

  • Organic Chemistry
  • Organometallic Chemistry
  • Catalysis

Background:

  • Carbon-fluorine (C-F) bond formation is challenging in organic synthesis.
  • Existing transition-metal-catalyzed fluorination methods primarily rely on palladium.
  • Developing new catalytic systems for C-F bond formation is crucial for accessing functionalized arenes.

Purpose of the Study:

  • To develop a novel catalytic system for carbon-fluorine bond formation.
  • To explore the use of silver as a transition metal catalyst for C-F bond formation.
  • To demonstrate the utility of silver catalysis in synthesizing aryl fluorides with broad functional group tolerance.

Main Methods:

  • Investigated silver-catalyzed cross-coupling reactions for C-F bond formation.
  • Screened various reaction conditions to optimize silver catalysis.
  • Evaluated the functional group tolerance and substrate scope of the developed method.

Main Results:

  • Successfully demonstrated silver catalysis for the formation of carbon-fluorine bonds.
  • This is the first report of using silver for carbon-heteroatom bond formation via cross-coupling.
  • The developed method exhibits unprecedented functional group tolerance and substrate scope compared to existing palladium-based fluorination reactions.

Conclusions:

  • Silver catalysis offers a new and effective strategy for carbon-fluorine bond formation.
  • This work expands the catalytic toolkit for synthesizing fluorinated organic compounds.
  • The broad applicability of this silver-catalyzed method holds significant promise for organic synthesis.