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Related Concept Videos

The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...

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Related Experiment Video

Updated: Jun 10, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Nanosized emulsions stabilized by semisolid polymer interphase.

Yoon Sung Nam1, Jin-Woong Kim, Jongwon Shim

  • 1Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. yoonsung@mit.edu

Langmuir : the ACS Journal of Surfaces and Colloids
|August 11, 2010
PubMed
Summary

This study presents a novel method for creating stable oil-in-water nanoemulsions using amphiphilic block copolymers. The developed poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) system offers excellent colloidal stability for various applications.

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Last Updated: Jun 10, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Area of Science:

  • Colloid and Surface Chemistry
  • Materials Science
  • Polymer Science

Background:

  • Nanoemulsions offer enhanced properties but often suffer from poor stability.
  • Stabilizing nanoemulsions typically involves surfactants or polymers that can degrade over time.
  • Developing robust emulsifying agents is crucial for practical nanoemulsion applications.

Purpose of the Study:

  • To introduce a new strategy for stabilizing oil-in-water nanoemulsions.
  • To utilize the temperature-dependent phase behavior of amphiphilic block copolymers for emulsion stabilization.
  • To demonstrate the efficacy of poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) as an emulsifier.

Main Methods:

  • Formation of a semisolid interphase via polymer/oil demixing below the copolymer's melting temperature.
  • Preparation of embryonic emulsions using a homogeneous polymer/oil mixture at elevated temperatures.
  • Reduction of emulsion size to the nanometer range via microfluidic homogenization.

Main Results:

  • Nanoemulsions stabilized by PEO-b-PCL exhibited exceptional colloidal stability.
  • No significant changes in size distribution were observed after 4 months at ambient temperature.
  • The nanoemulsions remained stable for 10 days at 60°C, demonstrating thermal resilience.

Conclusions:

  • PEO-b-PCL effectively stabilizes oil-in-water nanoemulsions through a unique semisolid interphase mechanism.
  • This approach provides a robust method for creating nanoemulsions with long-term structural integrity.
  • PEO-b-PCL is a promising material for developing stable nanoemulsion formulations for diverse applications.