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Related Experiment Video

Updated: Jun 10, 2026

A Protocol to Acquire the Degenerative Tenocyte from Humans
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Dystrophic calcification following neonatal heel-prick testing.

Ann-Maree Kurzydlo1, Rodney Hannaford

  • 1Department of Dermatology, Westmead Hospital, NSW, Australia. akurzydlo@telstra.com

The Australasian Journal of Dermatology
|August 11, 2010
PubMed
Summary

Dystrophic calcification, appearing as nodules on the heels of a young boy, was linked to repeated neonatal heel-prick tests. This common procedure may cause localized calcification in susceptible individuals.

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Area of Science:

  • Dermatology
  • Pediatrics
  • Pathology

Background:

  • Dystrophic calcification is a condition where calcium deposits form in damaged or degenerating tissue.
  • While often associated with aging or chronic conditions, its occurrence in pediatric patients requires investigation into potential iatrogenic causes.

Observation:

  • A 7-year-old boy presented with a 5-year history of asymptomatic, solitary nodules on the plantar surfaces of both heels.
  • Histopathological examination revealed hyperkeratosis and psoriasiform hyperplasia overlying areas of dystrophic calcification.

Findings:

  • The clinical presentation and microscopic findings were consistent with dystrophic calcification.
  • The likely etiology identified was repeated heel-prick tests performed during the neonatal period for blood glucose monitoring.

Implications:

  • This case highlights a potential, albeit rare, complication of neonatal heel-prick testing, suggesting localized tissue trauma can induce calcification.
  • Clinicians should consider iatrogenic causes, such as repeated heel-prick tests, in the differential diagnosis of pediatric heel nodules.
  • Further research could explore the specific mechanisms and prevalence of calcification following neonatal procedures.