Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-mediated immune responses to different formulations of a live-attenuated tetravalent dengue vaccine candidate in subjects living in dengue endemic and non-endemic regions.

Human vaccines & immunotherapeutics·2019
Same author

Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study.

BMC infectious diseases·2018
Same author

Epidemiology and Transmission of Respiratory Infections in Thai Army Recruits: A Prospective Cohort Study.

The American journal of tropical medicine and hygiene·2018
Same author

A Survey of Wilderness Medicine Analgesia Practice Patterns.

Wilderness & environmental medicine·2018
Same author

Clinical and laboratory predictors of influenza infection among individuals with influenza-like illness presenting to an urban Thai hospital over a five-year period.

PloS one·2018
Same author

Polytopic vaccination with a live-attenuated dengue vaccine enhances B-cell and T-cell activation, but not neutralizing antibodies.

Heliyon·2017
Same journal

Machine Learning-Based Drug Susceptibility Prediction from Candida Genomic Data.

International journal of antimicrobial agents·2026
Same journal

Vancomycin Penetration into Intra-abdominal Compartments: Site Concentration Disparities and Implications for Dose Optimization in Gram-Positive Infections.

International journal of antimicrobial agents·2026
Same journal

Strain-dependent variability in pharmacodynamic interactions for phage-antibiotic combinations in Pseudomonas aeruginosa.

International journal of antimicrobial agents·2026
Same journal

Carbapenem-resistant Enterobacterales across the UK: a nationwide study of carbapenemase testing and novel antimicrobial activity.

International journal of antimicrobial agents·2026
Same journal

Kidney Injury, Dialysis, and Mortality with Vancomycin Plus Piperacillin-Tazobactam or Cefepime.

International journal of antimicrobial agents·2026
Same journal

Ceftaroline pharmacokinetics on ECMO, a pediatric case report.

International journal of antimicrobial agents·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue conundrums.

Robert V Gibbons1

  • 1Department of Virology, Armed Forces Research Institute of Medical Research, Bangkok, Thailand. robert.gibbons@afrims.org

International Journal of Antimicrobial Agents
|August 11, 2010
PubMed
Summary
This summary is machine-generated.

Dengue virus, a growing global threat, presents diagnostic and vaccine challenges due to its multiple serotypes and unique disease manifestations like plasma leakage, not frank hemorrhage. A safe vaccine remains the best hope for controlling this arboviral infection.

More Related Videos

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen
06:00

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 10, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen
06:00

Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

Published on: January 26, 2024

Area of Science:

  • Arbovirology
  • Infectious Diseases
  • Public Health

Background:

  • Dengue virus is a prevalent arboviral infection in tropical and subtropical areas.
  • Dengue is an emerging disease with increasing geographic spread and severity.
  • The condition is significantly underreported globally.

Purpose of the Study:

  • To review the challenges associated with Dengue virus infection.
  • To discuss diagnostic difficulties and complications in vaccine development.
  • To highlight the controversial case definition of dengue hemorrhagic fever (DHF).

Main Methods:

  • This is a review article, synthesizing existing knowledge.
  • It focuses on challenges in diagnosis, serotype diversity, and immune responses.
  • It discusses the clinical presentation, emphasizing plasma leakage over hemorrhage.

Main Results:

  • Dengue virus infection presents diagnostic challenges due to four serotypes.
  • The hallmark of severe dengue (DHF) is plasma leakage, not frank hemorrhage.
  • Original antigenic sin complicates serological responses and vaccine development.

Conclusions:

  • Multiple dengue virus serotypes complicate diagnosis, treatment, and vaccine development.
  • A safe and effective dengue vaccine is crucial for disease control.
  • Addressing underreporting and refining case definitions are important public health goals.