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Updated: Jun 10, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
Published on: February 16, 2024
International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell
Henk Lokhorst1, Hermann Einsele, David Vesole
1Department of Hematology, University Medical Center Utrecht, Utrecht, the Netherlands. h.lokhorst@umcutrecht.nl
Purpose:
To define consensus statement regarding allogeneic stem-cell transplantation (Allo-SCT) as a treatment option for multiple myeloma (MM) on behalf of International Myeloma Working Group.
Patients And Methods:
In this review, results from prospective and retrospective studies of Allo-SCT in MM are summarized.
Results:
Although the introduction of reduced-intensity conditioning (RIC) has lowered the high treatment-related mortality associated with myeloablative conditioning, convincing evidence is lacking that Allo-RIC improves the survival compared with autologous stem-cell transplantation.
Conclusion:
New strategies are necessary to make Allo-SCT safer and more effective for patients with MM. Until this is achieved, Allo-RIC in myeloma should only be recommended in the context of clinical trials.
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