Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SCID mice as immune system models.

J M McCune1

  • 1Systemix Inc., Palo Alto, California, USA.

Current Opinion in Immunology
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

Severe combined immunodeficiency (SCID) in C.B-17 mice offers a unique model. These mice lack T and B cells, aiding research into lymphoid development in both mice and humans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques.

Mucosal immunology·2015
Same author

Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.

Genes and immunity·2011
Same author

HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.

Journal of virology·2008
Same author

HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
Same author

Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Lymphatic research and biology·2007
Same author

Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA.

Proceedings of the National Academy of Sciences of the United States of America·2002
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Area of Science:

  • Immunology
  • Developmental Biology
  • Genetics

Background:

  • C.B-17 scid/scid mice exhibit severe combined immunodeficiency (SCID).
  • This condition is characterized by a defect in T and B lymphocyte maturation.

Purpose of the Study:

  • To introduce C.B-17 scid/scid mice as a novel experimental system.
  • To investigate normal lymphoid differentiation and function.

Main Methods:

  • Utilizing the unique immunodeficient phenotype of C.B-17 scid/scid mice.
  • Comparative analysis of lymphoid development.

Main Results:

  • The SCID mouse model demonstrates a profound lack of mature T and B cells.
  • This provides a system to study lymphoid development without endogenous immune interference.

Related Experiment Videos

Conclusions:

  • C.B-17 scid/scid mice are a valuable tool for studying lymphoid biology.
  • This model system is applicable to understanding human and mouse immune development.