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Updated: Jun 10, 2026

09:52
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma
H Husein-Elahmed1, J L Callejas-Rubio, R Ortega Del Olmo
1Department of Dermatology, San Cecilio University Hospital, Granada, Spain. huseinelahmed@hotmail.com
Current Oncology (Toronto, Ont.)
|August 11, 2010
Abstract:
Melanoma is the most lethal form of skin malignancy because of its aggressive behaviour. In advanced disease, interferon alfa can be used as adjuvant therapy. However, this therapy is not free of side effects. We present a case of severe Raynaud syndrome and digital necrosis induced by interferon alfa in a patient with melanoma. Pathogenic mechanisms are discussed.
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