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Related Concept Videos

Lifestyle Factors and Health01:20

Lifestyle Factors and Health

Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Related Experiment Video

Updated: Jun 10, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Moving against frailty: does physical activity matter?

Francesco Landi1, Angela M Abbatecola, Mauro Provinciali

  • 1Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy.

Biogerontology
|August 11, 2010
PubMed
Summary
This summary is machine-generated.

Regular physical activity is crucial for older adults, combating frailty syndrome and its components like sarcopenia and cognitive decline. Exercise is not a contraindication but a vital intervention for improving health outcomes in the elderly.

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Published on: October 6, 2016

Area of Science:

  • Gerontology
  • Geriatric Medicine
  • Exercise Science

Background:

  • Frailty is a geriatric syndrome characterized by cumulative physiological declines and reduced stress resilience in older adults.
  • It increases vulnerability to adverse outcomes including disability, falls, hospitalization, and mortality.
  • Physical activity is recognized for its protective effects against frailty components.

Purpose of the Study:

  • To review the impact of physical activity on key components of the frailty syndrome.
  • To highlight exercise as a beneficial intervention for older adults experiencing frailty.

Main Methods:

  • This is a review article.
  • It synthesizes existing evidence on physical activity's role in frailty.
  • Specific focus on sarcopenia, functional impairment, cognitive performance, and depression.

Main Results:

  • Physical activity positively influences sarcopenia, functional capacity, and cognitive function in older adults.
  • Exercise can mitigate risks associated with cognitive decline and improve mood.
  • Frailty does not contraindicate physical activity; it often necessitates it.

Conclusions:

  • Physical activity is a cornerstone intervention for managing and potentially preventing frailty in older persons.
  • Regular exercise can improve multiple health domains affected by frailty, enhancing quality of life.
  • Prescribing physical exercise is essential for addressing frailty syndrome and its associated risks.