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Updated: Jun 10, 2026
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Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
Published on: November 29, 2018
Myeloid sarcoma involving the breast
Biljana Jelić-Puskarić1, Slobodanka Ostojić-Kolonić, Ana Planinc-Peraica
1Department of Medicine, Laboratory for Cytology and Hematology, "Merkur" University Hospital, Zagreb, Croatia. biljana.jelic.puskaric@zg.t-com.hr
Collegium Antropologicum
|August 12, 2010
Summary
Isolated myeloid sarcoma of the breast is rare, often presenting as a breast neoplasm. Early recognition is crucial for timely diagnosis and treatment of this aggressive condition.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Myeloid sarcoma is an extramedullary tumor of immature myeloid cells.
- It can precede, coincide with, or follow myeloid malignancies like acute myeloid leukemia (AML).
- Isolated myeloid sarcoma of the breast is an exceptionally rare presentation.
Observation:
- A case of a 25-year-old woman with a palpable left breast mass is presented.
- Fine needle aspiration revealed myeloblasts, leading to further investigation.
- The patient exhibited anemia, thrombocytopenia, leukocytosis, and peripheral/bone marrow blasts.
Findings:
- The diagnosis was acute myeloid leukemia without maturation.
- Despite intensive chemotherapy, the patient had a poor prognosis, succumbing within a year.
- This case highlights the diagnostic challenge of isolated breast myeloid sarcoma.
Implications:
- Myeloid sarcoma must be considered in the differential diagnosis of breast neoplasms.
- Timely diagnosis of breast myeloid sarcoma is critical for patient outcomes.
- Increased awareness can improve the detection of this rare extramedullary manifestation of myeloid disease.
