Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HALP Score in Predicting Post-Liver Transplant Outcomes in Patients with Hepatocellular Carcinoma.

Journal of clinical medicine·2026
Same author

Combined treatment with vitamin K2 and albumin inhibits growth in hepatocellular carcinoma cells by promoting differentiation and apoptosis.

Molecular biology reports·2026
Same author

A Network Phenotyping Strategy approach in a Turkish HCC Dataset and Comparison of Patients Selected for Transplant and those who were not.

Journal of Inonu Liver Transplantation Institute·2025
Same author

Transplant Versus Non-Transplant Hepatocellular Carcinoma Patient Characteristics And Survival.

World journal of medical oncology..·2025
Same author

A New Approach to Analysis of Clinical Data and Prognostication for Patients with Hepatocellular Carcinoma, Based Upon a Network Phenotyping Strategy (NPS) Computational Method.

Journal of Inonu Liver Transplantation Institute·2025
Same author

Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology·2025
Same journal

Palliative Surgery for Gastric Cancer with Gastric Outlet Obstruction or Anemia due to Tumor Bleeding.

Hepato-gastroenterology·2016
Same journal

A Novel "Artery First" Approach Allowing Safe Resection in Laparoscopic Pancreaticoduodenectomy: The Uncinate Process First Approach.

Hepato-gastroenterology·2016
Same journal

A Phase I Study of S-1 and Gemcitabine with Concurrent Radiotherapy in Patients with Non-Metastatic Advanced Pancreatic Cancer.

Hepato-gastroenterology·2016
Same journal

A Novel Approach for Endoscopic Papillary Balloon Dilation with the Guidewire Left in the Pancreatic Duct to Ensure Pancreatic Stenting.

Hepato-gastroenterology·2016
Same journal

Which Factors are Predictive for Mortality among Hospitalized Patients with Cirrhosis?

Hepato-gastroenterology·2016
Same journal

Hydrodynamics Analysis and CFD Simulation of Portal Venous System by TIPS and LS.

Hepato-gastroenterology·2016
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

HCC in young adults.

Brian I Carr1, Petr Pancoska, Robert A Branch

  • 1Liver Tumor Program, Kimmel Cancer Center, Dept of Medical Oncology, Thomas Jefferson University, Bluely Building, Room 519, 233 S. 10th Street, Philadelphia, PA 19107, USA. brianicarr@hotmail.com

Hepato-Gastroenterology
|August 12, 2010
PubMed
Summary
This summary is machine-generated.

This study on hepatocellular carcinoma (HCC) found younger patients clustered into survival groups, with hepatitis significantly impacting outcomes and tumor characteristics. Hepatitis-mediated factors may drive tumor development in these HCC patients.

More Related Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Related Experiment Videos

Last Updated: Jun 10, 2026

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Area of Science:

  • Hepatology
  • Oncology
  • Medical Statistics

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • Understanding prognostic factors in unresectable HCC is crucial for patient management.
  • Previous studies have identified various factors influencing HCC survival, but specific patterns in younger patient cohorts require further elucidation.

Purpose of the Study:

  • To analyze survival patterns in a large cohort of unresectable and untransplantable HCC patients.
  • To identify distinct sub-cohorts within younger HCC patients based on survival.
  • To investigate the influence of hepatitis and specific tumor characteristics on survival in these sub-cohorts.

Main Methods:

  • Retrospective analysis of a large cohort of biopsy-proven HCC patients.
  • Rank-ordering patients based on survival data.
  • Clustering analysis to identify age-related sub-cohorts.
  • Correlation analysis of serum biomarkers (AFP, GGTP) with tumor characteristics and survival.

Main Results:

  • A non-random clustering by age was observed, with three distinct sub-cohorts of younger patients exhibiting survival between 90-360 days.
  • One younger sub-cohort showed a predominance of female patients.
  • Serum alpha-fetoprotein (AFP) effectively monitored tumor number, while gamma-glutamyl transpeptidase (GGTP) better reflected tumor mass.
  • Hepatitis significantly impacted survival in younger patients, who presented with more numerous, smaller tumors, suggesting a hepatitis-mediated carcinogenic field defect.

Conclusions:

  • Younger patients with unresectable HCC form distinct survival clusters.
  • Hepatitis plays a critical role in the survival and tumor development of specific younger HCC patient groups.
  • Tumor monitoring requires distinct biomarkers for tumor number (AFP) and tumor mass (GGTP).