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Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
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Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
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Published on: April 19, 2017

[Immunobiologically active compounds from skin].

O V Belova, V Ia Arion, Iu M Lopukhin

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |August 12, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified three immunologically active compounds from porcine skin. One compound, K-activin, inhibits human fibroblast proliferation and shows weak anaphylactic reactions, offering insights into immune responses.

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    Area of Science:

    • Immunology
    • Biochemistry
    • Dermatology

    Context:

    • Investigating the immunomodulatory properties of compounds derived from animal tissues.
    • Understanding the role of specific molecules in immune system regulation.

    Purpose:

    • To characterize the physiochemical and biological properties of three immunologically active compounds from porcine skin.
    • To evaluate the inhibitory effects of these compounds on fibroblast proliferation and anaphylactic reactions.

    Summary:

    • Three immunologically active compounds were extracted from porcine skin using acetone.
    • High-pressure gel chromatography and RP-HPLC revealed the heterogeneity of these compounds, particularly compound 2 (K-activin).
    • K-activin demonstrated inhibition of human fetal fibroblast proliferation and weak activity in general and skin anaphylactic reactions.

    Impact:

    • Provides a detailed characterization of novel immunologically active compounds from porcine skin.
    • Highlights K-activin as a potential agent for modulating fibroblast proliferation and immune responses.
    • Contributes to the understanding of immunomodulation and potential therapeutic applications in immunology and dermatology.