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Related Experiment Video

Updated: Jun 10, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Second primary melanomas: incidence and outcome.

Matthew R Bower1, Charles R Scoggins, Robert C G Martin

  • 1Surgical Oncology, University of Louisville, Louisville, Kentucky 40202, USA. matt.bower@louisville.edu

The American Surgeon
|August 12, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Patients with melanoma have a 1.9% incidence of developing multiple primary melanomas (MPM). Older age, specific melanoma subtypes, and lack of lymphovascular invasion (LVI) are associated with MPM development. Close surveillance is crucial for early detection.

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Epidemiology

Background:

  • Melanoma patients have an increased risk of developing subsequent primary melanomas and other malignancies.
  • Understanding risk factors for multiple primary melanomas (MPM) is crucial for patient management and surveillance strategies.

Purpose of the Study:

  • To determine the incidence of multiple primary melanomas (MPM) and other cancer types in patients initially diagnosed with melanoma.
  • To identify factors associated with the development of MPM in melanoma patients.

Main Methods:

  • Post hoc analysis of a multi-institutional prospective randomized trial involving 2506 melanoma patients (aged 18-70, Breslow thickness ≥1 mm).
  • Kaplan-Meier analysis was used to evaluate disease-free survival (DFS) and overall survival (OS).

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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Last Updated: Jun 10, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

  • Multivariate analysis identified factors associated with MPM development.

    • Main Results:

    • The incidence of MPM was 1.9% (48/2506 patients) over a median follow-up of 66 months.
    • Subsequent melanomas were significantly thinner than the primary tumor (median 0.32 mm vs. 1.50 mm).
    • Factors associated with MPM included older age, superficially spreading melanoma (SSM) subtype, negative sentinel lymph nodes, and absence of lymphovascular invasion (LVI).
    • Patients with MPM showed similar DFS but significantly better OS (5-year OS 95.3% vs. 80.0%) compared to single primary melanoma patients.
    • Nonmelanoma malignancies occurred in 6.1% of patients.

    Conclusions:

    • Ongoing surveillance of melanoma patients is essential due to the significant risk of developing additional melanomas and other cancers.
    • Early detection of second primary melanomas through close follow-up is typically achieved.
    • Specific patient and tumor characteristics predict the development of multiple primary melanomas.