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Related Concept Videos

Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...

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Related Experiment Video

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Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
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Published on: February 23, 2016

Dynamic dissolution: a step closer to predictive dissolution testing?

Mark McAllister1

  • 1Research Formulation, Pfizer PGRD, Sandwich, Kent, CT13 9NJ, UK. mark.mcallister@pfizer.com

Molecular Pharmaceutics
|August 12, 2010
PubMed
Summary

Traditional dissolution baths struggle to mimic the body's complex environment. This review explores advanced, noncompendial dissolution models that better assess oral drug delivery system performance under physiological conditions.

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Area of Science:

  • Pharmaceutical Science
  • Drug Delivery Systems
  • Biopharmaceutics

Background:

  • Compendial dissolution techniques are standard for evaluating oral drug delivery systems.
  • Traditional dissolution baths lack the dynamic capabilities to simulate the gastrointestinal environment.
  • This limitation hinders accurate prediction of in vivo drug performance.

Purpose of the Study:

  • To review noncompendial dissolution models.
  • To highlight their ability to overcome traditional method limitations.
  • To offer tools for assessing drug performance under physiologically relevant conditions.

Main Methods:

  • Literature review of noncompendial dissolution models.
  • Analysis of model designs and their physiological relevance.
  • Comparison with compendial dissolution methods.

Main Results:

  • Noncompendial models offer enhanced simulation of gastrointestinal conditions.
  • These models provide more accurate insights into drug release kinetics.
  • They address the dynamic nature of the GI tract.

Conclusions:

  • Noncompendial dissolution models are crucial for advancing drug delivery research.
  • They offer superior physiological relevance compared to compendial methods.
  • These models improve the prediction of in vivo oral drug performance.