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Intramolecular [1 + 4 + 1] cycloaddition: establishment of the method

Douglass F Taber1, Pengfei Guo, Na Guo

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberdf@udel.edu

Journal of the American Chemical Society
|August 12, 2010
PubMed
Summary

This study introduces a novel two-step [1 + 4 + 1] method for synthesizing complex bicyclic and polycyclic natural products. This new procedure offers a valuable alternative to the widely used intramolecular Diels-Alder cycloaddition for constructing intricate molecular architectures.

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