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Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
Six different assemblies from one building block: two-dimensional crystallization of an amide amphiphile
1Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Abstract:
A C(s)-symmetric amide amphiphile containing a C(18) alkyl chain exists in at least six crystalline phases at the liquid/solid interface; several of these phases display regularly arranged nanoscopic voids. Structural analysis of each phase reveals that highly symmetric and/or complex patterns arise through adopting various aggregates via noncovalent interactions, several of which are mediated by the unique hydrogen-bonding properties of the primary amide. The formation of each phase is interpreted in the context of the kinetic and thermodynamic behaviors, with some phases showing concentration-dependent stabilities, while others are purely kinetic in origin. This investigation contributes to understanding the factors that give rise to solid form diversity in two- and three-dimensional crystallization.
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