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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Obesity modulation - the role in carcinogenesis.

Ioannis Legakis1, Kostantinos Syrigos

  • 1Department of Endocrinology and Metabolism, Henry Dunant Hospital, Athens, Greece. ilegak@med.uoa.gr

Anti-Cancer Agents in Medicinal Chemistry
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PubMed
Summary

Obesity and metabolic syndrome increase cancer risk. This review explores how metabolic markers influence tumor growth and their future clinical applications in oncology.

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Area of Science:

  • Oncology
  • Metabolic Syndrome Research
  • Cancer Etiology

Background:

  • Obesity is a significant risk factor for numerous serious medical conditions, including many cancers.
  • Metabolic syndrome and visceral obesity are increasingly prevalent globally, affecting a substantial portion of the US and European populations.
  • Emerging evidence suggests a link between metabolic syndrome and cancer development, with implications for the health industry.

Purpose of the Study:

  • To review current data on the role of metabolic markers in tumor cell growth.
  • To explore the relationship between metabolic markers, obesity, metabolic syndrome, and cancer.
  • To discuss the future clinical prospects of targeting metabolic pathways in cancer treatment.

Main Methods:

  • Literature review of epidemiologic, basic research, clinical, and intervention studies.
  • Analysis of data on the prevalence of obesity and metabolic syndrome.
  • Examination of the interaction between cancer cells and adipocytes.

Main Results:

  • Increased body weight and metabolic syndrome are associated with a higher risk of various cancers.
  • Specific metabolic markers are implicated in the development and progression of malignancies.
  • The interaction between adipose tissue and cancer cells is a key area of tumor biology.

Conclusions:

  • Metabolic syndrome may be an important etiological factor in cancer onset.
  • Metabolic markers play a crucial role in tumor cell proliferation and malignancy.
  • Understanding these metabolic pathways offers potential for future clinical cancer management strategies.