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Updated: Jun 10, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
[Haemorrhages due to vitamin C deficiency. Scurvy in the 21st century]
Maykel Michiels1, Marieke Mellema, Frank P J Peters
1Orbis Medisch Centrum, Afd. Interne geneeskunde, Sittard-Geleen, the Netherlands.
Abstract:
A 68-year-old female with an extensive history of unexplained problems presented at the Department of Internal Medicine for an analysis of painful cutaneous abnormalities of the lower legs. A systemic cause could not be found. Later on the general practitioner noted haematoma and petechiae and subsequently a hypovitaminosis C. The patient received active vitamin C supplement for this. The cutaneous abnormalities on the legs had significantly improved after 3 weeks. This patient was found to have symptomatic hypovitaminosis C, also known as scurvy, as a complication of an psychiatric disorder. Although scurvy might appear to be a disease of the past that rarely occurs nowadays, it should nevertheless be given due consideration. This requires a good history taking.
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