Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Rapid Identification of Pathogens01:25

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Molecular pathology in tumour classification: the present and future molecular revolution].

Nederlands tijdschrift voor geneeskunde·2014
Same author

[Task differentiation, in pathology as well].

Nederlands tijdschrift voor geneeskunde·2013
Same author

[Virtual autopsy--why not?].

Nederlands tijdschrift voor geneeskunde·2012
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia
09:56

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia

Published on: March 6, 2026

[Pathology also subject to RCTs].

J L G Hans Blaauwgeers1

  • 1Onze Lieve Vrouwe Gasthuis, afd. Pathologie, Amsterdam, the Netherlands. hansblaauwgeers@pathology.nl

Nederlands Tijdschrift Voor Geneeskunde
|August 12, 2010
PubMed
Summary

Randomized controlled trials (RCTs) are crucial for advancing pathology diagnostics, especially with new molecular techniques. Evidence-based pathology reporting and verifiable diagnostic roles are essential for patient care.

Area of Science:

  • Diagnostic pathology
  • Molecular pathology
  • Evidence-based medicine

Context:

  • Pathology, a diagnostic field, traditionally excludes patient treatment, seemingly limiting its role in randomized controlled trials (RCTs).
  • Pathology serves as a critical diagnostic benchmark in numerous RCTs and clinical guidelines.
  • Emerging molecular techniques enhance objectivity in pathology diagnostics.

Purpose:

  • To explore the applicability and growing importance of RCTs in pathology.
  • To highlight the integration of molecular pathology in diagnostic accuracy.
  • To emphasize the need for evidence-based pathology reporting.

Summary:

  • Pathology, while diagnostic, is integral to RCTs, particularly with advancements in molecular techniques yielding more objective data.

Related Experiment Videos

Last Updated: Jun 10, 2026

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia
09:56

A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia

Published on: March 6, 2026

  • A recent RCT investigated electronic reminders for Lynch syndrome diagnostics, detectable via microsatellite instability testing.
  • Future research will likely focus on evidence-based pathology reporting and verifying pathology's role in patient diagnosis and treatment.

    • Impact:

    • Enhances the scientific rigor of pathology diagnostics through RCTs.
    • Facilitates the adoption of objective, molecular-based diagnostic methods.
    • Promotes evidence-based practices and verifiable roles for pathology in patient management.