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Related Experiment Video

Updated: Jun 10, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Integrative computed tomographic imaging of cardiac structure, function, perfusion, and viability.

Christian Thilo¹, Michael Hanley, Gorka Bastarrika

¹Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29401, USA.

Cardiology in Review

|August 12, 2010

Summary

Multidetector-row computed tomography (MDCT) advances cardiac imaging, offering validated coronary artery stenosis evaluation and "triple rule out" for chest pain. Newer scanners aim to overcome heart rate limitations for comprehensive coronary heart disease assessment.

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Published on: April 18, 2013

Area of Science:

Cardiovascular Imaging
Radiology
Medical Technology

Background:

Multidetector-row computed tomography (MDCT) has significantly improved cardiac imaging capabilities.
MDCT, particularly 64-slice coronary computed tomography angiography, is validated for assessing coronary artery stenosis.
The technology enables simultaneous evaluation for acute coronary syndrome, pulmonary embolism, and acute aortic syndrome, known as "triple rule out".

Purpose of the Study:

To highlight recent advancements in MDCT for cardiac imaging.
To discuss the current applications and limitations of MDCT in evaluating coronary artery disease.
To explore the future potential of MDCT for comprehensive, integrated cardiac imaging.

Main Methods:

Review of recent technological developments in MDCT scanners.
Analysis of clinical validation studies for coronary computed tomography angiography.
Discussion of ongoing research into multi-parametric MDCT applications.

Main Results:

MDCT, especially 64-slice coronary computed tomography angiography, shows high negative predictive values for ruling out coronary artery stenosis.
MDCT facilitates the "triple rule out" strategy for acute chest pain evaluation.
Current MDCT technology faces limitations with high or irregular heart rates.

Conclusions:

MDCT is a primary tool for evaluating coronary artery stenosis and has advanced acute chest pain diagnostics.
Future MDCT generations promise to overcome existing limitations, particularly heart rate variability.
MDCT is being investigated as a comprehensive, single-modality solution for integrative imaging of coronary heart disease.