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Related Experiment Video

Updated: Jun 10, 2026

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver
07:06

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver

Published on: February 6, 2018

Reducing leukocyte trafficking preserves hepatic function after sepsis.

Toan Huynh1, Nhat Nguyen, Steven Keller

  • 1F.H. Sammy Ross Jr. Trauma Center, Carolinas Medical Center, Charlotte, North Carolina 28232-2861, USA. toan.huynh@carolinashealthcare.org

The Journal of Trauma
|August 12, 2010
PubMed
Summary
This summary is machine-generated.

Activated protein C (aPC) reduces leukocyte trafficking in sepsis, preserving liver function and improving survival. This study highlights aPC

Related Experiment Videos

Last Updated: Jun 10, 2026

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver
07:06

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver

Published on: February 6, 2018

Area of Science:

  • Sepsis research
  • Hepatology
  • Immunology

Background:

  • Sepsis can cause liver dysfunction due to leukocyte trafficking.
  • Activated protein C (aPC) may protect the liver by reducing leukocyte adhesion.

Purpose of the Study:

  • To investigate if aPC can preserve hepatic function in sepsis by reducing leukocyte-endothelial interactions.

Main Methods:

  • Rats underwent sepsis induction (cecal ligation and puncture) or sham surgery.
  • Animals received saline or aPC treatment.
  • Liver function, cytokine levels, and leukocyte trafficking were assessed.

Main Results:

  • Sepsis increased mortality, inflammatory cytokines (IL-2, IL-6, IL-8), and liver injury markers.
  • Leukocyte adhesion increased, and velocity decreased in septic rats.
  • aPC treatment reduced mortality, inflammation, and preserved liver function.

Conclusions:

  • Sepsis-induced hepatic dysfunction is partly mediated by increased leukocyte trafficking.
  • aPC treatment attenuates leukocyte trafficking, preserving liver function and improving survival.
  • Protein C-dependent leukocyte-endothelial interactions play a critical role in sepsis.