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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Atypical fibroxanthoma with keloidal collagen
Jacqueline N Fussell1, Elizabeth R Cooke, Frances Florentino
1Medical College of Georgia, Augusta, 30904, USA. jfussell@students.mcg.edu
The American Journal of Dermatopathology
|August 12, 2010
Summary
Atypical fibroxanthoma (AFX), a skin neoplasm, can present with keloidal collagen. This rare histopathologic finding suggests a distinctive presentation of AFX on sun-damaged skin.
Area of Science:
- Dermatopathology
- Oncology
- Surgical Pathology
Background:
- Atypical fibroxanthoma (AFX) commonly affects sun-exposed skin, particularly the head and neck.
- Histopathological examination of AFX typically shows atypical cells with positive vimentin and CD10 staining.
- AFX is a rare soft tissue neoplasm.
Observation:
- A unique case of AFX exhibited keloidal collagen upon histopathological analysis.
- This specific histopathologic feature is infrequently reported in existing literature.
Findings:
- The presence of keloidal collagen in AFX represents a distinctive histopathological finding.
- Immunohistochemical markers like vimentin and CD10 are characteristic of AFX.
Implications:
- Recognizing this variant presentation of AFX is crucial for accurate diagnosis.
- Further research may elucidate the significance of keloidal collagen in AFX pathogenesis.
- This finding contributes to the understanding of AFX spectrum.
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