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All-cause mortality of patients with dyslipidemia up to 19 years after a multidisciplinary lifestyle modification

Lena Håglin1, Sara Lundström, Gunnar Kaati

  • 1Department of Public Health and Clinical Medicine, Family Medicine, University of Umeå, Sweden.

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
|August 12, 2010
PubMed

Insights

A comprehensive lifestyle modification program significantly reduced long-term all-cause mortality in patients with dyslipidemia. This intervention demonstrated a sustained benefit, highlighting its effectiveness for cardiovascular risk reduction.

Area of Science:

  • Cardiovascular Health
  • Preventive Medicine
  • Public Health

Background:

  • Individual lifestyle factors are linked to cardiovascular and all-cause mortality.
  • Previous studies indicated risk reductions from comprehensive lifestyle programs.
  • The study aimed to evaluate long-term mortality outcomes in patients undergoing lifestyle modification for cardiovascular disease prevention.

Purpose of the Study:

  • To assess the long-term impact of a lifestyle modification program on all-cause mortality.
  • To determine if the program's benefits varied by diagnosis (dyslipidemia, hypertension, type 2 diabetes, coronary heart disease).

Main Methods:

  • A randomized trial involving 325 patients, with 239 randomized to the lifestyle program and 86 to usual care.
  • The program included a 4-week residential intervention focusing on diet and exercise, with follow-up visits at 1 and 5 years.
  • All-cause mortality was tracked for 11-12 years and 18-19 years post-intervention.

Main Results:

  • Patients with dyslipidemia showed a 76% relative risk reduction (RRR) in all-cause mortality at 11-12 years (HR 0.24, P=0.033).
  • This significant RRR for dyslipidemia patients persisted at 18-19 years, with a 66% reduction (HR 0.34, P=0.026).
  • No significant RRR in all-cause mortality was observed for patients with hypertension, type 2 diabetes, or coronary heart disease.

Conclusions:

  • The lifestyle modification program achieved a significant and sustained long-term reduction in all-cause mortality specifically for patients with dyslipidemia.
  • These findings underscore the importance of targeted lifestyle interventions for individuals with specific cardiovascular risk factors.
Abstract

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