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Updated: Jun 10, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Genetics, Peking University School of Oncology, Beijing Cancer Hospital & Institute, 52 Fucheng Rd. Hai Dian District, 100142 Beijing, People's Republic of China.
Background:
The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear.
Methods:
Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China.
Results:
In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54-0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC.
Conclusions:
Water source and other factors in this region need further evaluation by longitudinal studies.
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