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Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

Updated: Jun 10, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
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[Persistent neutropenia].

S Bürki1, Andreas Oestmann, D Vogel

  • 1Universitätsklinik für Allgemeine Innere Medizin, Inselspital, Universitätsspital Bern, Bern.

Praxis
|August 12, 2010
PubMed
Summary
This summary is machine-generated.

A 72-year-old patient with persistent neutropenia was diagnosed with immune neutropenia and systemic lupus erythematosus. Treatment with steroids effectively managed the symptoms, indicating a successful therapeutic approach.

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The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
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Related Experiment Videos

Last Updated: Jun 10, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
05:52

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
07:17

The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood

Published on: February 7, 2025

Area of Science:

  • Internal Medicine
  • Hematology
  • Rheumatology

Background:

  • Persistent neutropenia can be a challenging diagnostic puzzle, often requiring thorough investigation.
  • Sialadenitis, inflammation of salivary glands, can sometimes be an incidental finding during the workup of other conditions.
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.

Observation:

  • A 72-year-old patient presented with persistent neutropenia, initially investigated in the context of sialadenitis.
  • Further diagnostic evaluation revealed the co-existence of immune neutropenia and systemic lupus erythematosus.
  • The clinical presentation and history made drug-induced lupus erythematosus an unlikely cause.

Findings:

  • The patient was diagnosed with immune neutropenia and systemic lupus erythematosus.
  • A trial of steroid therapy was initiated.
  • Steroid maintenance therapy resulted in good symptomatic control.

Implications:

  • This case highlights the importance of considering autoimmune disorders in patients with unexplained neutropenia.
  • Early diagnosis and appropriate management, such as with corticosteroids, can lead to favorable outcomes in patients with immune neutropenia and SLE.
  • Understanding the interplay between different autoimmune conditions is crucial for comprehensive patient care.