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YKL-40: a new biomarker in cardiovascular disease?
Anders Bruun Mathiasen1, Kristoffer Mads Aaris Henningsen, Marina Jurjevna Harutyunyan
1Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, Copenhagen University Hospital and Faculty of Health Sciences, DK-2100 Copenhagen, Denmark.
Insights
The protein YKL-40 shows promise as a novel biomarker for cardiovascular disease, aiding in predicting disease severity and prognosis. Further research will explore its role in monitoring treatment effectiveness.
Area of Science:
- Biochemistry
- Cardiology
- Biomarker Discovery
Background:
- Coronary artery disease remains a leading cause of mortality in Western countries despite advancements in treatment.
- Current treatments for cardiovascular disease have improved survival rates but many patients still experience significant symptoms and poor prognoses.
- There is an unmet need for novel biomarkers to enhance early prediction and precision in cardiovascular disease management.
Purpose of the Study:
- To explore the current knowledge regarding YKL-40 as a potential biomarker in cardiovascular disease.
- To assess the utility of YKL-40 in predicting cardiovascular disease severity and prognosis.
- To investigate the potential of YKL-40 as a supplementary biomarker for cardiovascular prevention.
Main Methods:
- Review of existing scientific literature on YKL-40 and cardiovascular disease.
- Analysis of current evidence on YKL-40's role as a biomarker in both cardiovascular and noncardiovascular diseases.
- Exploration of YKL-40's potential application in disease severity assessment and prognosis prediction.
Main Results:
- YKL-40 is identified as a potential new biomarker for cardiovascular disease.
- Current evidence suggests YKL-40 is valuable as a marker for disease severity, prognosis, and short-term survival.
- YKL-40 functions as an independent biomarker in both cardiovascular and noncardiovascular conditions.
Conclusions:
- YKL-40 presents potential as an independent biomarker for cardiovascular disease, offering insights into severity and prognosis.
- Future studies are warranted to determine YKL-40's efficacy in monitoring treatment responses across diverse patient populations.
- YKL-40 may serve as a valuable tool to complement existing biomarkers in cardiovascular disease prevention and management.
Abstract:
Cardiovascular disease in the form of coronary artery disease is the most common cause of death in western countries. Early treatment with stabilizing drugs and mechanical revascularization by percutaneous coronary intervention or coronary bypass surgery has reduced the mortality significantly. But in spite of improved treatments, many patients are still plagued by a high frequency of angina symptoms, hospitalizations and a poor prognosis. There is a need for new independent or supplementary biomarkers that can help to predict cardiovascular disease and cardiovascular events earlier and more precisely, and thus accompany existing biomarkers in both primary and secondary cardiovascular prevention. One such potential new biomarker is the protein YKL-40. As an independent biomarker in both cardiovascular diseases and noncardiovascular diseases, current evidence suggests YKL-40 to be most useful as a marker of disease severity, prognosis and short survival. However, future studies will evaluate whether YKL-40 can be used for monitoring of the treatment effect in different patient populations with a distinct disease diagnosis. In this article we explore present knowledge on YKL-40 as a biomarker in cardiovascular disease.
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