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Related Experiment Videos

High dose busulfan and seizures.

R De La Camara1, J F Tomas, A Figuera

  • 1Department of Hematology, Hospital de la Princesa, Madrid, Spain.

Bone Marrow Transplantation
|May 1, 1991
PubMed
Summary

High-dose busulfan in bone marrow transplants can cause seizures, even with preventative medication. Researchers emphasize the need for effective anticonvulsant prophylaxis to manage this risk.

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Bone marrow transplantation·2022

Area of Science:

  • Hematology
  • Neuroscience
  • Pharmacology

Background:

  • Busulfan is a key chemotherapeutic agent used in conditioning regimens for bone marrow transplantation.
  • Seizures are a known, though rarely emphasized, potential adverse effect of high-dose busulfan therapy.

Observation:

  • Three cases of busulfan-associated convulsions were observed in 28 bone marrow transplant recipients.
  • Convulsions occurred despite the use of anticonvulsant prophylaxis in two of the three patients.

Findings:

  • The reported seizures were generalized, with no lasting neurological deficits or recurrences.
  • This suggests that convulsions may be a more frequent side effect of high-dose busulfan than commonly reported.

Implications:

  • Clinicians should be aware of the potential for busulfan-induced seizures.
  • The findings underscore the importance of implementing robust and efficient anticonvulsant prophylactic strategies in patients receiving high-dose busulfan.

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