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Translumbar inferior vena cava catheters.
W D Haire1, R P Lieberman, G B Lund
1Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3330.
Bone Marrow Transplantation
|May 1, 1991
Summary
Daily aspirin significantly reduces catheter thrombosis in patients undergoing stem cell collection via translumbar inferior vena cava (IVC) catheters. This safe intervention improves apheresis procedure success rates, making it a valuable consideration for patient care.
Area of Science:
- Hematology
- Transplantation Medicine
- Vascular Access
Background:
- Translumbar inferior vena cava (IVC) catheters are essential for peripheral blood stem cell (PBSC) collection.
- Thrombotic obstruction is a frequent complication, occurring in approximately 20% of cases.
- Effective strategies to prevent catheter-related thrombosis are needed.
Purpose of the Study:
- To evaluate the efficacy of daily aspirin in reducing thrombotic obstruction of translumbar IVC catheters.
- To assess the impact of aspirin on the success rate of apheresis procedures for PBSC collection.
Main Methods:
- A prospective study involving patients undergoing PBSC collection via translumbar IVC catheters.
- Patients received aspirin 325 mg daily starting post-catheter placement until collection completion.
- Outcomes were compared to historical control data.
Main Results:
- Aspirin significantly reduced catheter thrombosis from 20% (12/60) to 3.2% (1/31) (p = 0.007).
- The incidence of thrombus-free apheresis procedures increased significantly (p = 0.024) with aspirin use.
- No adverse effects of aspirin were observed during stem cell collection.
Conclusions:
- Daily aspirin (325 mg) is a safe and effective method to prevent thrombotic obstruction in translumbar IVC catheters.
- Aspirin administration improves the success rate of apheresis procedures for PBSC collection.
- Consideration of daily aspirin is recommended for patients receiving translumbar IVC catheters for stem cell collection.