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Drug target in eosinophilic meningitis caused by Angiostrongylus cantonensis

Kittisak Sawanyawisuth1, Kanlayanee Sawanyawisuth

  • 1Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. kittisak@kku.ac.th

Infectious Disorders Drug Targets
|August 13, 2010
PubMed

Insights

Eosinophilic meningitis, an emerging infectious disease caused by Angiostrongylus cantonensis, is diagnosed via clinical signs and exposure history. Corticosteroids are currently the only effective treatment for this condition.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Parasitology

Background:

  • Eosinophilic meningitis is primarily caused by the parasitic nematode Angiostrongylus cantonensis.
  • It represents the most frequent manifestation of human angiostrongyliasis.
  • The disease is increasingly recognized as a significant public health concern.

Purpose of the Study:

  • To summarize the key aspects of eosinophilic meningitis due to Angiostrongylus cantonensis.
  • To highlight diagnostic criteria and effective therapeutic interventions.

Main Methods:

  • Diagnosis relies on clinical presentation, specifically identifying eosinophils in cerebrospinal fluid.
  • Patient history includes potential exposure to Angiostrongylus cantonensis larvae, often through consumption of raw snails or contaminated produce.

Main Results:

  • The presence of cerebrospinal fluid eosinophilia is a hallmark diagnostic indicator.
  • A history of exposure to the parasite is crucial for diagnosis.

Conclusions:

  • Corticosteroids are identified as the sole effective treatment for eosinophilic meningitis caused by Angiostrongylus cantonensis.
  • Early diagnosis and prompt corticosteroid administration are vital for patient outcomes.

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