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Other Glycolytic Pathways01:24

Other Glycolytic Pathways

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The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
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Magnetic Susceptibility and Permeability01:31

Magnetic Susceptibility and Permeability

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In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
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C4 Pathway and CAM01:27

C4 Pathway and CAM

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
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Susceptibility, Permittivity and Dielectric Constant01:26

Susceptibility, Permittivity and Dielectric Constant

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When placed in an external electric field, a dielectric material gets polarized. The charge density in the dielectric material is given by the sum of the bound and free charge densities, while the total charge density can also be written in terms of the total electric field. The bound charge density can be measured in terms of polarization, leading to the relationship between electric displacement and polarization.
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Auditory Pathway01:15

Auditory Pathway

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Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
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ER Retrieval Pathway01:45

ER Retrieval Pathway

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In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
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Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

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Shared pathways to infectious disease susceptibility?

Chiea C Khor1, Martin L Hibberd

  • 1Infectious Diseases, Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, 138672 Singapore. khorcc@gis.a-star.edu.sg.

Genome Medicine
|August 13, 2010
PubMed
Summary
This summary is machine-generated.

Genomic association testing advances understanding of human immune response in infectious diseases. New methods reveal disease susceptibility genes and highlight distinct pathogen detection mechanisms across illnesses.

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Area of Science:

  • Genetics and Immunology
  • Infectious Disease Research

Background:

  • Genomic association testing has evolved from microsatellite markers to genome-wide association scans.
  • This progression enables a more comprehensive understanding of human immune response in infectious disease outcomes.

Discussion:

  • Technological advancements are unraveling complex infectious diseases.
  • These approaches are beginning to dissect pathogen-specific human immune responses.

Key Insights:

  • Robust discovery of numerous disease susceptibility genes.
  • Preliminary findings suggest pathogen innate detection mechanisms differ across diseases, unlike broader immune response mechanisms.

Outlook:

  • Further research into pathogen-host interactions.
  • Potential for targeted therapeutic strategies based on distinct immune responses.