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Quetiapine-associated cholestasis causing lipoprotein-X and pseudohyponatraemia
J A Klinke1, S C Shapira, E Akbari
1Department of Medicine, Royal Columbian Hospital, New Westminster, British Columbia, Canada.
Abstract:
A case of intrahepatic cholestasis secondary to treatment with quetiapine in combination with lamotrigine and zopiclone, resulting in severe hypercholesterolaemia without overt lactescence of the plasma, is presented. Abundant lipoprotein-X was seen on lipoprotein electrophoresis. The patient was diagnosed and treated for hyponatraemia which was likely factitious and caused by hypercholesterolaemia. Cholestasis and hypercholesterolaemia resolved over a period of several months after the discontinuation of quetiapine.
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