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Coupled for cross-presentation in tumor immunotherapy

Baoxu Pang1, Jacques Neefjes

  • 1Division of Cell Biology, Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.

Science Translational Medicine
|August 13, 2010
PubMed

Antigen cross-presentation is a critical step in the elicitation of cell-mediated immune responses. Much research has been aimed at manipulating antigen cross-presentation to improve tumor immunotherapy and vaccination. In this issue of Science Translational Medicine, Saccheri et al. describe a mechanism for spurring successful antitumor responses by enhancing the transfer, to antigen-presenting cells, of tumor-specific antigens that leave the cancer cells via gap junctions induced by Salmonella infection of the melanoma tumor. Salmonella turns from foe to friend by promoting cross-presentation for strong antitumor immunity and tumor eradication.

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