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Novel functions for NFκB: inhibition of bone formation

Susan A Krum1, Jia Chang, Gustavo Miranda-Carboni

  • 1UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Nature Reviews. Rheumatology
|August 13, 2010
PubMed

Insights

Nuclear Factor kappa B (NFκB) negatively regulates bone formation. Reduced NFκB activity in osteoblasts increases bone formation by enhancing JNK signaling, offering potential therapeutic targets for bone diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

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