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Updated: Jun 10, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
Published on: July 8, 2012
Innate immunity as orchestrator of stem cell mobilization.
M Z Ratajczak1, C H Kim, W Wojakowski
1Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA. mzrata01@louisville.edu
Hematopoietic stem and progenitor cells (HSPCs) mobilize into peripheral blood during injury or inflammation. Mounting evidence suggests innate immunity orchestrates this conserved stem cell mobilization process.
Area of Science:
- Stem cell biology
- Immunology
- Hematopoiesis
Background:
- Hematopoietic stem and progenitor cells (HSPCs) and other stem cells circulate in peripheral blood (PB).
- Stem cell numbers in PB increase during stress, inflammation, and tissue injury.
- Stem cell mobilization is crucial for immune surveillance and tissue regeneration.
Purpose of the Study:
- To review evidence on the role of innate immunity in orchestrating stem cell mobilization.
- To highlight the evolutionary conservation of this stem cell mobilization mechanism.
- To discuss the implications of stem cell mobilization in hematological transplantology.
Main Methods:
- Literature review of existing research on stem cell mobilization.
- Analysis of the role of innate immunity in triggering stem cell release.
- Examination of pharmacological agents used to enhance stem cell mobilization.
Main Results:
- Stem cell mobilization is a conserved response to tissue damage, hypoxia, and infection.
- Innate immunity plays a central role in orchestrating stem cell mobilization.
- Pharmacological agents enhance HSPC mobilization for hematopoietic reconstitution.
Conclusions:
- Innate immunity is a key regulator of hematopoietic stem and progenitor cell mobilization.
- Understanding this mechanism is vital for regenerative medicine and transplantation.
- Stem cell mobilization is an evolutionarily conserved danger-sensing response.
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