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Updated: Jun 10, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Genitourinary functioning and depressive symptoms over time in younger versus older men treated for prostate cancer
Katherine J Roberts1, Stephen J Lepore, Alexandra L Hanlon
1Department of Health and Behavior Studies, Teachers College Columbia University, 525 West 120th Street, New York, NY 10027, USA. kjr20@columbia.edu
Background/Purpose:
This study examined the relation of age to genitourinary functioning and depressive symptoms over time and examined how age influences the relation between genitourinary functioning and depressive symptoms over time in men treated for localized prostate cancer.
Methods:
Participants were 234 men who completed interviews that assessed genitourinary functioning and depressive symptoms at 2, 4, 10 and 16 months after treatment. Analyses were statistically controlled for potential confounds.
Results:
Compared with younger men (≤ 65.5), older men had significantly poorer sexual function and slower improvement. Level of urinary functioning was inversely associated with level of depressive symptoms regardless of age. Level of sexual functioning was inversely associated with level of depressive symptoms but only in younger men.
Conclusion:
Interventions may be particularly helpful for all men with urinary dysfunction and for younger men with sexual dysfunction in order to improve symptoms of depression.
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