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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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[Past and present of pneumonia]

P Altucci1, A Parlato

  • 1Clinica Medica Generale, Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale F. Magrassi A. Lanzara, Seconda Università degli Studi di Napoli. paolo.altucci@unina2.it

Annali Di Igiene : Medicina Preventiva E Di Comunita
|August 13, 2010
PubMed

Insights

Pneumonia has evolved, with a shift from socially-transmitted infections to more complex hospital-acquired types. Modern pneumonias frequently involve multidrug-resistant Gram-negative bacteria and atypical pathogens.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pulmonology

Context:

  • Historical comparison of pneumonia prevalent during Vincenzo Cuomo's active period versus contemporary cases.
  • Distinction between community-acquired (socially-transmitted) and hospital-acquired pneumonias.
  • Emergence of multidrug-resistant Gram-negative bacteria as a significant cause of nosocomial pneumonia.

Purpose:

  • To compare the epidemiological characteristics and causative agents of pneumonia across different time periods.
  • To highlight the changing landscape of pneumonia etiology, including the rise of antibiotic resistance.
  • To identify emerging and persistent pathogens responsible for pneumonia.

Summary:

  • Community-acquired pneumonias are contrasted with hospital-acquired infections, which are increasingly caused by multidrug-resistant Gram-negative bacteria.
  • Pneumonias caused by atypical pathogens such as mycoplasmas, rickettsiae, and Legionella are discussed.
  • Viral etiologies, including Cytomegalovirus, are also considered as significant contributors to pneumonia.

Impact:

  • Provides insights into the evolving nature of pneumonia, crucial for public health strategies.
  • Informs clinical practice regarding diagnosis and treatment of contemporary pneumonia cases.
  • Highlights the growing challenge of antimicrobial resistance in managing respiratory infections.

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