Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Side-effects of fluoride therapy.

M Laroche, B Mazières

    Bailliere'S Clinical Rheumatology
    |April 1, 1991
    PubMed
    Summary
    This summary is machine-generated.

    Fluoride treatment for osteoporosis increases bone density but may not improve bone strength. While serious fractures are rare, patients may experience more stress fractures and joint pain, with ongoing debate on its overall risk-benefit balance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Loss of bone mineral density in hemiplegic patients after stroke: Prospective single-center study.

    Revue neurologique·2022
    Same author

    Consequence of vertebral fracture cascades: about a cohort of 79 patients.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
    Same author

    Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model.

    Human molecular genetics·2020
    Same author

    Frequency of isolated cutaneous involvement in adult mastocytosis: a cohort study.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019
    Same author

    Higher prevalence of vertebral fractures in systemic mastocytosis, but not in cutaneous mastocytosis and idiopathic mast cell activation syndrome.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
    Same author

    Olfactory bulb atrophy and caspase activation observed in the BACHD rat models of Huntington disease.

    Neurobiology of disease·2019

    Area of Science:

    • Bone metabolism and osteoporosis treatment.

    Background:

    • Fluoride is utilized to stimulate bone formation, particularly for treating vertebral osteoporosis.
    • Studies indicate that fluoride-induced bone is denser but not necessarily stronger than normal bone.

    Purpose of the Study:

    • To evaluate the efficacy and safety of fluoride in osteoporosis treatment.
    • To assess the risk-benefit ratio of fluoride therapy.

    Main Methods:

    • Review of epidemiological and experimental studies on fluoride's effects on bone.
    • Analysis of fracture rates and side-effects associated with fluoride treatment.

    Main Results:

    • True fractures (cortical rupture) occur in approximately 5% of patients, similar to untreated osteoporotic individuals.
    • Stress fractures and arthralgia are more common (around 30%) but typically have a benign prognosis.

    Related Experiment Videos

  • Improved digestive tolerance with modern formulations.

    • Conclusions:

    • Fluoride increases bone density but its impact on bone strength is variable.
    • The higher incidence of stress fractures and arthralgia requires consideration.
    • The overall risk-benefit profile of fluoride for osteoporosis remains under discussion.