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Updated: Jun 10, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Acyclic stereocontrol in the catalytic C-H amination of benzylic methylene groups
Anike Nörder1, Pavel Herrmann, Eberhard Herdtweck
1Lehrstuhl für Organische Chemie I and Catalysis Research Center, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.
Abstract:
Diastereotopos-differentiation is the key feature of the catalytic C-H amination at the benzylic position of substrate 1. Essentially independent of the functional group X (X = COOMe, PO(OEt)(2), SO(2)Ph, NO(2), CN, OAc), the depicted products 2 are formed with good (dr = 80/20) to excellent (dr > 95/5) diastereoselectivity. The reaction proceeds without racemization and possesses potential for the C-H amination of open-chain substrates.
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