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Updated: Jun 10, 2026

Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools

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Published on: October 1, 2007

Nanotechnology-enabled medicine.

Mauro Ferrari¹

¹The Ohio State University, 473 West 12th Ave., Columbus, OH 43210, USA.

Discovery Medicine

|August 14, 2010

Summary

This summary is machine-generated.

Cancer mortality rates remain unchanged since 1950 due to challenges in treating metastatic disease. Developing targeted therapies is crucial for effective cancer treatment with minimal side effects.

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Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools

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Development of New Therapeutic Applications Using Microfluidics

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

Area of Science:

Oncology
Cancer Therapeutics
Molecular Biology

Background:

Cancer mortality rates in the U.S. have not significantly decreased since 1950, despite scientific advancements.
A primary challenge in cancer treatment is the inability to effectively manage metastatic disease when surgery or radiation are not options.

Purpose of the Study:

To highlight the persistent challenge of cancer treatment selectivity.
To discuss the limitations of current systemic therapies in targeting cancer cells without harming healthy tissues.

Main Methods:

Review of existing challenges in cancer therapy, focusing on selectivity.
Examination of systemic treatment approaches including chemical and biological agents.
Analysis of the three key components of treatment selectivity: delivery, recognition, and localized action.

Main Results:

Cancer treatment progress is hindered by the difficulty in selectively targeting cancer cells.
Systemic therapies face challenges in achieving selectivity, leading to unwanted side effects.
Molecularly targeted therapies show promise by focusing on specific cancer-associated biological features.

Conclusions:

Overcoming the challenge of treatment selectivity is essential for improving cancer patient outcomes.
Molecularly targeted therapies represent a significant advancement in achieving precise cancer cell intervention.
Targeting specific molecular pathways, like EGFR mutations or BCR-ABL kinase, offers a more effective and less toxic approach to cancer treatment.