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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

Macro trends in pharmaceutical innovation.

Fredric J Cohen¹

¹Crownstone, 3331 Street Road, Suite 140, Bensalem, PA 19020, USA.

Discovery Medicine

|August 14, 2010

Summary

The pharmaceutical industry innovates, balancing pioneering and incremental advancements. While critics view some drugs as imitative, these incremental innovations offer medical benefits and sustain industry profits.

Area of Science:

Pharmaceutical Industry Analysis
Innovation Studies
Health Economics

Background:

The pharmaceutical industry faces criticism regarding its innovation output and incentives.
A debate exists on whether innovations are truly novel or merely imitative ('me-too' drugs).
Lack of universally accepted metrics hinders definitive conclusions on industry innovation.

Purpose of the Study:

To analyze trends in pharmaceutical innovation using multiple metrics.
To evaluate the industry's balance between pioneering and incremental innovation.
To assess the medical value and economic role of incremental innovations.

Main Methods:

Analysis of trends across several innovation metrics.
Examination of industry motivation, effort, and ability to innovate.

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Comparison with innovation patterns in other mature manufacturing industries.

Main Results:

Evidence suggests the industry values and pursues pioneering innovations.
The industry heavily relies on incremental innovations for profitability, similar to other mature sectors.
Incremental innovations, often termed 'me-too' drugs, provide significant medical benefits.

Conclusions:

The pharmaceutical industry demonstrates a dual approach to innovation, valuing both pioneering and incremental advancements.
Incremental innovations are crucial for sustaining profits and offer considerable medical value.
Dismissing incremental innovations as solely imitative overlooks their contribution to patient care and industry viability.