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Virilization secondary to topical testosterone.

L U Parker1, W F Bergfeld

  • 1Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195.

Cleveland Clinic Journal of Medicine
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Topical testosterone for vulvar lichen sclerosus can cause severe virilization, contrary to common belief. Close monitoring for androgenic side effects is crucial, with alternatives like corticosteroids recommended.

Area of Science:

  • Dermatology
  • Endocrinology

Background:

  • Topical testosterone is a standard treatment for vulvar lichen sclerosus et atrophicus.
  • Systemic androgenic side effects are generally considered uncommon and mild.

Observation:

  • A case study documented severe hirsutism and virilization in a patient using topical testosterone propionate.
  • Markedly elevated serum testosterone levels were observed.

Findings:

  • Topical testosterone therapy can lead to significant systemic androgenic effects.
  • These effects, including virilization, may be more common and severe than previously thought.

Implications:

  • Clinicians should exercise caution when prescribing topical testosterone for vulvar lichen sclerosus.

Related Experiment Videos

  • Close patient monitoring for signs of virilization is essential.
  • Alternative treatments such as intralesional corticosteroids or topical progesterone should be considered to mitigate risks.