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A novel effector protein modulates response regulator activity without altering phosphorylation

Patrick D Curtis1, Yves V Brun

  • 1Department of Biology, Indiana University, Bloomington, IN 47405, USA.

Molecular Cell
|August 14, 2010
PubMed

Insights

A novel protein in Caulobacter crescentus prevents the activation of the global regulator CtrA without changing its phosphorylation state. This finding explains how CtrA-regulated genes are silenced during specific cell cycle stages.

Area of Science:

  • Cell biology
  • Microbiology
  • Molecular biology

Background:

  • The global transcriptional regulator CtrA controls cell cycle progression in Caulobacter crescentus.
  • CtrA activity is regulated by phosphorylation, which typically activates its function.
  • Genes under CtrA control are not expressed during certain cell cycle stages, despite CtrA activation.

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