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Related Concept Videos

Microtubule Instability02:17

Microtubule Instability

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...
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Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Related Experiment Video

Updated: Jun 10, 2026

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps
03:01

Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps

Published on: August 2, 2024

Microsatellite instability in endometrial polyps.

Salete S Rios1, Rosângela V Andrade, Rinaldo W Pereira

  • 1Molecular Pathology Post-graduated Program, University of Brasilia, Brasilia, DF, Brazil. saleterios@ig.com.br

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|August 14, 2010
PubMed
Summary
This summary is machine-generated.

Microsatellite instability (MSI) is infrequent in endometrial polyps, occurring in 6.4% of cases. While MSI may be more common in polyps with simple hyperplasia without atypia, this finding was not statistically significant.

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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

Area of Science:

  • Gynecology
  • Oncology
  • Molecular Biology

Background:

  • Microsatellite instability (MSI) is a known biomarker in various cancers.
  • Its prevalence and clinical significance in endometrial polyps are not well-established.

Purpose of the Study:

  • To determine the frequency of MSI in endometrial polyps.
  • To identify any associated clinical or histopathological factors.

Main Methods:

  • Prospective collection of 109 endometrial polyp samples.
  • MSI analysis using NCI-recommended markers.
  • Histopathological examination and clinical data review.

Main Results:

  • MSI was detected in 6.4% (7/109) of samples.
  • MSI was more frequent in polyps with simple hyperplasia without atypia (15%).
  • No significant associations found with patient demographics or menopausal status.

Conclusions:

  • MSI is infrequent in endometrial polyps.
  • A potential association between MSI and simple hyperplasia without atypia warrants further investigation.
  • This study provides initial prospective data on MSI in endometrial polyps.