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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Related Experiment Video

Updated: Jun 10, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long non-coding RNAs: Guardians of development.

Selina van Leeuwen¹, Harald Mikkers

¹Department of Molecular Cell Biology, Regenerative Medicine Program, Leiden University Medical Center, Postal zone S1P, P.O. Box 9600, 2300RC Leiden, The Netherlands.

Differentiation; Research in Biological Diversity

|August 14, 2010

Summary

This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial regulators of gene transcription and cell signaling. This review explores how lncRNAs orchestrate developmental programs by modulating gene expression.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

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Area of Science:

Genomics
Molecular Biology
Developmental Biology

Background:

Long non-coding RNAs (lncRNAs) were discovered two decades ago.
Initially dismissed as transcriptional noise, emerging data highlight their regulatory roles.
Non-coding RNAs (ncRNAs) are now recognized for their importance in transcription and cell signaling.

Purpose of the Study:

To discuss the mechanisms of lncRNA-mediated transcriptional regulation.
To review evidence linking lncRNAs to developmental programs.
To elucidate the role of specific lncRNA subsets in development.

Main Methods:

Literature review of lncRNA research.
Analysis of studies on lncRNA function in gene regulation.
Synthesis of evidence connecting lncRNAs to developmental processes.

Main Results:

lncRNAs are not transcriptional noise but functional molecules.
Specific lncRNAs significantly impact gene transcription.
These lncRNAs play a key role in orchestrating major developmental programs.

Conclusions:

lncRNAs are critical regulators of gene expression.
A subset of lncRNAs is essential for normal development.
Further research into lncRNA mechanisms will advance our understanding of development.