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Updated: Jun 10, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
The association between birth condition and neuropsychological functioning and educational attainment at school age:
David E Odd1, Andrew Whitelaw, David Gunnell
1Southmead Hospital, Bristol, Avon, UK. david.odd@bristol.ac.uk
Insights
Infants resuscitated at birth but without encephalopathy showed no difference in neurodevelopmental outcomes compared to non-resuscitated infants. However, those developing encephalopathy had poorer cognitive and language skills and required more educational support.
Area of Science:
- Neonatal care
- Neurodevelopmental outcomes
- Pediatric neurology
Background:
- Birth condition can impact neurodevelopment, but effects beyond IQ are not fully understood.
- Infants requiring resuscitation may face risks, even without clinical encephalopathy.
Purpose of the Study:
- To investigate if resuscitation at birth affects attention, memory, and language skills in children.
- To determine if resuscitation influences the need for educational support in the absence of encephalopathy.
Main Methods:
- Study included term infants from the Avon Longitudinal Study of Parents and Children.
- Compared three groups: resuscitated without encephalopathy, resuscitated with encephalopathy, and non-resuscitated controls.
- Assessed neurodevelopmental measures and educational support needs between ages 8-11, adjusting for covariates.
Main Results:
- Resuscitated infants without encephalopathy had similar neurodevelopmental scores to controls.
- Infants with encephalopathy showed significantly lower working memory, reading accuracy, and comprehension scores.
- Infants with encephalopathy had a higher risk of needing educational support.
Conclusions:
- Resuscitation without subsequent encephalopathy does not appear to impair neurodevelopmental functioning.
- Neonatal encephalopathy is associated with poorer neuropsychological outcomes and increased educational support needs.
- The study highlights the long-term impact of neonatal encephalopathy on cognitive and language development.
Objective:
Poor condition at birth may impact on IQ, although its effect on other measures of neurodevelopment is unclear. The authors' aim was to determine whether infants receiving resuscitation after birth have reduced scores in measures of attention, memory and language skills or the need for educational support at school even in the absence of clinical encephalopathy.
Methods:
Three groups of term infants were identified from the Avon longitudinal study of parents and children: infants resuscitated at birth but asymptomatic for encephalopathy (n=612), infants resuscitated who developed symptoms of encephalopathy (n=40) and the reference infants who were not resuscitated and had no further neonatal care (n=8080). Measures of attention, language, memory and the need for educational support were obtained for children between 8 years and 11 years. Test results (standardised to a mean of 100 and SD of 15) were adjusted for clinical and social covariates. Missing covariate data were imputed using chained equations.
Results:
Infants asymptomatic after resuscitation had similar scores to those not requiring resuscitation for all measures while infants who developed encephalopathy had lower working memory (-6.65 (-12.34 to -0.96)), reading accuracy (-7.95 (-13.28 to -2.63)) and comprehension (-9.32 (-14.47 to -4.17) scores and increased risk of receiving educational support (OR 6.24 (1.52 to 26.43)) than infants thought to be well at birth, although there was little evidence for an association after excluding infants who developed cerebral palsy.
Conclusions:
The authors found no evidence that infants who were resuscitated but remained well afterwards differed from those not requiring resuscitation in the aspects of neuropsychological functioning assessed in this study. Infants who developed neonatal encephalopathy had evidence of worse functioning, particularly in language skills and were more likely to receive educational support at school.
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