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Related Experiment Videos

Marijuana-derived material-induced changes in monkey ciliary processes differ from those in rabbit ciliary processes.

T F McDonald1, L Cheeks, T Slagle

  • 1Department of Anatomy, Medical College of Georgia, Augusta 30912-3400.

Current Eye Research
|April 1, 1991
PubMed
Summary

Intravitreal marijuana-derived material (MDM) caused severe ciliary swelling and lower intraocular pressure (IOP) in monkeys. Intravenous MDM caused only moderate swelling without IOP changes, unlike in rabbits.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Background:

  • Water-soluble marijuana-derived material (MDM) effects on ocular structures and intraocular pressure (IOP) are not fully understood.
  • Previous studies in rabbits showed significant ciliary swelling and IOP decrease after intravenous (IV) MDM injection.

Purpose of the Study:

  • To investigate the morphologic changes in ciliary processes and associated IOP in owl and squirrel monkeys following intravitreal (IVT) and IV injections of MDM.
  • To compare the ocular response to MDM in monkeys with previously reported responses in rabbits.

Main Methods:

  • Owl and squirrel monkeys received IVT and IV injections of water-soluble MDM.
  • Morphologic changes in ciliary processes were examined.
  • Intraocular pressure (IOP) was monitored.

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Main Results:

  • IVT injection of MDM induced severe swelling in monkey ciliary processes, accompanied by a decrease in IOP.
  • IV injection of MDM resulted in moderate ciliary process swelling, including basal lamina disruption, but no significant IOP change.
  • Monkey responses to IV MDM differed from rabbit responses, potentially due to differences in ciliary stroma compactness.

Conclusions:

  • The route of MDM administration significantly impacts ocular response and IOP in monkeys.
  • Monkey ciliary processes exhibit a distinct response to IV MDM compared to rabbits.
  • Further research into the anatomical differences may explain species-specific variations in MDM ocular effects.