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Related Experiment Videos

Plasma glucagon in insulinoma.

A Ohneda, K Matsuda, K Horigome

    Acta Diabetologica Latina
    |September 1, 1977
    PubMed
    Summary

    Patients with insulinoma show normal fasting plasma glucagon, but elevated levels in malignant cases. Plasma glucagon correlates with insulin, with an exaggerated response to arginine infusion.

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    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Insulinoma is a rare tumor causing hypoglycemia due to excessive insulin production.
    • Understanding the role of glucagon in insulinoma is crucial for managing glucose homeostasis.

    Purpose of the Study:

    • To investigate fasting plasma glucagon levels in insulinoma patients.
    • To assess the plasma glucagon response to tolbutamide and arginine challenges.

    Main Methods:

    • Studied nine patients diagnosed with insulinoma.
    • Measured fasting plasma glucagon, insulin, and blood glucose levels.
    • Administered tolbutamide and arginine infusions, monitoring glucagon response.

    Main Results:

    • Fasting plasma glucagon was normal, except in two malignant insulinoma cases.
    • A significant positive correlation was observed between plasma glucagon and plasma insulin.
    • Tolbutamide did not alter glucagon levels; arginine infusion induced an exaggerated glucagon response in most patients.

    Conclusions:

    • Plasma glucagon levels are generally normal in insulinoma but can be elevated in malignant forms.
    • Glucagon secretion is closely linked to insulin levels in insulinoma.
    • Arginine stimulation is a valuable test for revealing abnormal glucagon secretion patterns in insulinoma.

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