Lipid disturbances in psoriasis: an update

Area of Science:

• Dermatology
• Immunology
• Metabolic Science

Background:

• Psoriasis affects 2-3% of the population and is influenced by diverse factors.
• It is increasingly recognized as a systemic disease with multiorgan complications.
• Dyslipidemia is a frequent comorbidity in psoriasis patients.

Purpose of the Study:

• To review literature on lipid metabolism in psoriasis.
• To explore the connection between inflammation, lipid parameters, and clinical symptoms.
• To characterize psoriasis as an immunometabolic disease.

Main Methods:

• Literature review of studies on psoriasis and lipid metabolism.
• Analysis of research focusing on skin lipids, serum lipids, and lipoproteins.
• Examination of oxidative stress and inflammatory markers.

Main Results:

• Extensive research exists on skin and serum lipid alterations in psoriasis.
• Studies investigate dermal low-density lipoproteins and epidermal phospholipids.
• Correlations between inflammatory markers, lipid profiles, and disease severity are explored.

Conclusions:

• Psoriasis involves significant alterations in lipid metabolism.
• The disease exhibits characteristics of an immunometabolic condition.
• Understanding these links is crucial for managing psoriasis comorbidities.