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Related Experiment Video

Updated: Jun 10, 2026

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
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Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Rank Protein Immunolabeling during Bone-Implant Interface Healing Process.

Francisley Avila Souza1, Thallita Pereira Queiroz, Eloá Rodrigues Luvizuto

  • 1Department of Surgery and General Clinical, Araçatuba Dental School, Universidade Estadual Paulista, UNESP, Rua José Bonifácio 1190, Bloco 10A, Vila Mendonça, 16015-050 Araçatuba, Brazil.

International Journal of Dentistry
|August 14, 2010
PubMed
Summary

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This study investigated Receptor Activator of Nuclear Factor kappa-B (RANK) protein expression during bone healing around implants. RANK was found in osteoblasts and osteoclasts, peaking early in the healing process.

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Cell Biology

Background:

  • Bone healing is crucial for implant osseointegration.
  • Understanding cellular signaling pathways involved in bone regeneration is essential.
  • Receptor Activator of Nuclear Factor kappa-B (RANK) plays a role in bone remodeling.

Purpose of the Study:

  • To evaluate the expression of RANK protein during the bone-healing process around machined surface implants.
  • To investigate the cellular localization of RANK in bone cells interacting with the implant surface.

Main Methods:

  • Histological analysis of bone tissue samples from rats with titanium implants.
  • Immunohistochemical staining for RANK protein.
  • Quantitative evaluation of RANK expression at 7, 14, 21, and 42 days post-implantation.

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

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Last Updated: Jun 10, 2026

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:32

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Published on: December 30, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Main Results:

  • RANK protein expression was detected in both osteoblast and osteoclast lineage cells.
  • A significant increase in RANK expression was observed in osteoblasts at 7 days post-surgery.
  • RANK expression gradually decreased throughout the bone healing timeline, with minimal cellular activity noted in later stages.

Conclusions:

  • RANK immunolabeling was predominantly observed in osteoclast and osteoblast cells at the bone-implant interface during early bone healing.
  • RANK expression dynamics suggest its involvement in the initial stages of osseointegration and bone remodeling around implants.