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Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
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Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...

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CMV enteritis causing massive intestinal hemorrhage in an elderly patient.

Mihaiela Morunglav1, Ivan Theate, Gilles Bertin

  • 1Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.

Case Reports in Medicine
|August 14, 2010
PubMed
Summary

Cytomegalovirus (CMV) enteritis caused massive intestinal bleeding in an immunocompetent elderly patient. Early antiviral therapy is crucial for this rare condition, even in those without prior immune compromise.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pathology

Background:

  • Cytomegalovirus (CMV) disease is uncommon in immunocompetent individuals.
  • Aging may be associated with subtle immune system decline.
  • CMV infection can manifest in the gastrointestinal tract.

Observation:

  • A 72-year-old immunocompetent patient presented with diarrhea and abdominal pain.
  • Initial investigations suggested duodenitis and suspected vasculitis, leading to steroid therapy.
  • The patient experienced severe, recurrent intestinal bleeding requiring surgery.

Findings:

  • Histological examination of surgical specimens confirmed CMV vasculitis causing jejunitis.
  • Ganciclovir treatment was initiated following the diagnosis.
  • No further bleeding occurred after antiviral therapy.

Implications:

  • CMV enteritis is a rare but serious cause of gastrointestinal hemorrhage, particularly in the elderly.
  • This case highlights the importance of considering CMV in immunocompetent patients with unexplained enteritis and bleeding.
  • Prompt diagnosis and antiviral treatment are essential for managing CMV-induced intestinal complications.